Comparative analysis of coiled-coil prediction methods
نویسندگان
چکیده
منابع مشابه
Comparative analysis of coiled-coil prediction methods.
In this study we compare commonly used coiled-coil prediction methods against a database derived from proteins of known structure. We find that the two older programs COILS and PairCoil/MultiCoil are significantly outperformed by two recent developments: Marcoil, a program built on hidden Markov models, and PCOILS, a new COILS version that uses profiles as inputs; and to a lesser extent by a Pa...
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The α-helical coiled-coil domain is a protein structure motif with a characteristic repeat pattern well suited for computer-based prediction. Long coiled-coil proteins play an important role in organizational and regulatory processes within cells and have been implicated in a number of human diseases. Knowledge about plant or prokaryotic long coiled-coil proteins however has been limited to a f...
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MOTIVATION The coiled coil is a ubiquitous α-helical protein-structure domain that directs and facilitates protein-protein interactions in a wide variety of biological processes. At the protein-sequence level, the coiled coil is readily recognized via a conspicuous heptad repeat of hydrophobic and polar residues. However, structurally coiled coils are more complicated, existing in a wide range ...
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The coiled-coil structure is a typical hyper-secondary structure formed by the mutual intertwining of multiple alpha-helices, and is predicted as the structure of keratin of the intermediate filament by Crick in 1952 [2]. In 1988, the leucine zipper in the structure of transcription factors was found to be a form of the coiled-coil, and in succeeding years, a variety of biological applications ...
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Selective dimerization of the basic-region leucine-zipper (bZIP) transcription factors presents a vivid example of how a high degree of interaction specificity can be achieved within a family of structurally similar proteins. The coiled-coil motif that mediates homo- or hetero-dimerization of the bZIP proteins has been intensively studied, and a variety of methods have been proposed to predict ...
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ژورنال
عنوان ژورنال: Journal of Structural Biology
سال: 2006
ISSN: 1047-8477
DOI: 10.1016/j.jsb.2006.03.009